![]() Significant direct effects of variables of interest were identified, as well as gender-specific moderation of genetic risk on this SNP by social experiences. The current study examined the influence of gender, negative and positive daily life events, and GABRA 2 genotype ( SNP rs 279871) on alcohol dependence, testing two- and three-way interactions between these variables using multilevel regression models fit to data from 2,281 White participants in the Collaborative Study on the Genetics of Alcoholism. Gender-moderated gene–environment interactions are rarely explored, raising concerns about inaccurate specification of etiological models and inferential errors. Bucholz, Kathleen Edenberg, Howard Kramer, John Kuperman, Samuel Schuckit, Marc Alan Nurnberger, John I. ![]() Gender-Specific Gene–Environment Interaction in Alcohol Dependence: The Impact of Daily Life Events and GABRA 2
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